Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

Base Information

Chemical Name:Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate
CAS No.:138694-28-7
Molecular Formula:C₃₈H₆₃NO₁₀Si
Molecular Weight:722.004
Hs Code.:

Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

Synonyms:Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

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Chemical Property of Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

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Technology Process of Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

There total 22 articles about Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 138694-12-9
Bis(2,2,2-trifluoroethyl) 3-(methoxycarbonyl)-3-methylprop-2-enylphosphonate

: 138694-27-6
(2R,3R,4E,6S,7R,8S,10S,11R)-<(tert-Butyldimethylsilyl)oxy>-11-(2,5-dimethoxy-3-nitrophenyl)-8-hydroxy-N,7,8,11-tetramethoxy-N,2,4,6,10-pentamethyl-4-undecenal

: 138694-28-7
Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

: 145514-10-9
Methyl (2E,4E,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

Guidance literature:: With n-butyllithium; In diethyl ether; at -78 ℃; Yields of byproduct given;
DOI:10.1021/jo00030a006

Reference yield: 70.0%

: 138694-12-9
Bis(2,2,2-trifluoroethyl) 3-(methoxycarbonyl)-3-methylprop-2-enylphosphonate

: 138694-27-6
(2R,3R,4E,6S,7R,8S,10S,11R)-<(tert-Butyldimethylsilyl)oxy>-11-(2,5-dimethoxy-3-nitrophenyl)-8-hydroxy-N,7,8,11-tetramethoxy-N,2,4,6,10-pentamethyl-4-undecenal

: 138694-28-7
Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

: (2E,4E,8E)-(6S,10S,11R,12S,14S,15R)-7-(tert-Butyl-dimethyl-silanyloxy)-15-(2,5-dimethoxy-3-nitro-phenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-pentadeca-2,4,8-trienoic acid methyl ester

Guidance literature:: With n-butyllithium; In diethyl ether; Yields of byproduct given;
DOI:10.1016/S0040-4039(98)02638-0

Reference yield:

: 99968-60-2,27652-16-0
methyl (E)-4-bromo-2-methylbut-2-enoate

: 138694-28-7
Methyl (2E,4Z,6S,7R,8E,10S,11R,12S,14S,15R)-7-(tert-Butyldimethylsiloxy)-15-(2,5-dimethoxy-3-nitrophenyl)-11,12,15-trimethoxy-2,6,8,10,14-pentamethyl-2,4,8-pentadecatrienoate

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / 1 h / 110 °C

2: PCl₅ / 1) 2 h, r.t., 2) 6 h, 75 deg C

3: Huenig's base / benzene / 1) 30 min, 0 deg C, 2) 13 h, r.t.

4: 1) n-BuLi / 1) Et₂O, a) -78 deg C, 15 min, b) -20 deg C, 15 min 2) Et₂O, -78 deg C to -60 deg C, 4 h

With n-butyllithium; phosphorus pentachloride; N-ethyl-N,N-diisopropylamine; In benzene;
DOI:10.1021/jo00054a035