macbecin I

Base Information

• Chemical Name: macbecin I
• CAS No.: 130740-44-2
• Molecular Formula: C₃₀H₄₂N₂O₈
• Molecular Weight: 558.672
• Mol file: 130740-44-2.mol

Synonyms:

Chemical Property of macbecin I

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of macbecin I

There total 113 articles about macbecin I which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Decarbamoyl (+)-Macbecin I (78919-24-1) + sodium isocyanate (917-61-3) → macbecin I (130740-44-2,73341-72-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 25 ℃; for 3h;

DOI:10.1039/P19900000047

Reference yield: 71.0%

sodium isocyanate (917-61-3) + (4E,6Z,10E)-(8S,9R,12S,13R,14R,16S,17R)-9-Hydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-2-aza-bicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaene-3,20,22-trione (74804-35-6,78919-24-1) → macbecin I (73341-72-7,130740-44-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo00030a006

Reference yield: 37.0%

1,4-Dimethylmacbecin II (123084-01-5) → macbecin I (130740-44-2,73341-72-7)

Guidance literature:

With ammonium cerium(IV) nitrate; In water; acetonitrile; at 0 ℃; for 0.133333h;

DOI:10.1039/P19900000047

upstream raw materials:

Decarbamoyl (+)-Macbecin I

sodium isocyanate

1,4-Dimethylmacbecin II

(E)-(2R,3R,6S,7R,8S,10S,11R)-11-(2,5-Dimethoxy-3-nitro-phenyl)-7,8,11-trimethoxy-3-(4-methoxy-benzyloxy)-2,4,6,10-tetramethyl-undec-4-enal

Downstream raw materials:

(E)-2-Methyl-4-oxo-but-2-enoic acid {5-[3-(5-acetyl-3-methoxy-4-methyl-tetrahydro-furan-2-yl)-1-methoxy-2-methyl-propyl]-3,6-dioxo-cyclohexa-1,4-dienyl}-amide

Carbamic acid (4E,6Z,10E)-20,22-dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-aza-bicyclo[16.3.1]docosa-1⁽²²⁾,4,6,10,18,20-hexaen-9-yl ester

macbecin II diacetate

macbecin II