(E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile

Base Information

• Chemical Name: (E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile
• CAS No.: 127034-07-5
• Molecular Formula: C₁₉H₁₇NO₄
• Molecular Weight: 323.348
• Mol file: 127034-07-5.mol

Synonyms:(E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile

Chemical Property of (E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of (E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile

There total 1 articles about (E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) + 4-cyanobenzaldehyde (105-07-7) → (E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile (127034-07-5)

Guidance literature:

With sodium hydroxide; In methanol; for 0.666667h;

DOI:10.1016/j.ejmech.2006.08.012

Reference yield: 90.0%

(E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile (127034-07-5) → 4-(3-oxo-3-(3,4,5-trimethoxyphenyl)propyl)benzonitrile

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; formaldehyd; water; potassium carbonate; In toluene; at 110 ℃; for 18h; chemoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/ejoc.201403359

Reference yield: 70.0%

(E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile (127034-07-5) + 4-nitrothiobenzamide (26060-30-0,34496-30-5) → (E)-1-(3,4,5-trimethoxyphenyl)-3-{4-[5-(4-nitrophenyl)-1,2,4-thiadiazol-3-yl]phenyl}prop-2-en-1-one

Guidance literature:

(E)-4-(3-oxo-3-(3,4,5-trimethoxyphenyl)prop-1-en-1-yl)benzonitrile; 4-nitrothiobenzamide; With aluminum (III) chloride; In acetic acid butyl ester; at 70 ℃; for 5h;

With water; In acetic acid butyl ester; at 20 ℃; for 24h;

DOI:10.1134/S1070363219020257

upstream raw materials:

methyl (3,4,5-trimethoxyphenyl) ketone

4-cyanobenzaldehyde