4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone

Base Information

• Chemical Name: 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone
• CAS No.: 301693-64-1
• Molecular Formula: C₁₉H₁₆F₂O₂S
• Molecular Weight: 346.398

Synonyms:4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone

Chemical Property of 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone

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Technology Process of 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone

There total 1 articles about 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-bromo-2-methylpropanoyl cyanide (55106-47-3) + 2-(3,5-difluorophenyl)-1-[4-(methylthio)phenyl]ethanone → 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone (301693-64-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/S0968-0896(01)00388-1

Reference yield: 91.0%

4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone (301693-64-1) → 2,2-Dimethyl-4-(3,5-difluorophenyl)-5-{4-(methylsulfinyl)phenyl}-3(2H)-furanone

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/j.bmcl.2004.01.048

Reference yield:

oxone + 4-[3,5-(difluoro)phenyl]-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)furanone (301693-64-1) → 4-(3,5-difluorophenyl)-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone

Guidance literature:

In tetrahydrofuran; ethanol; water;

upstream raw materials:

2-bromo-2-methylpropanoyl cyanide

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