(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one
CAS No.:866148-41-6
Molecular Formula:C₃₂H₄₇NO₇Si
Molecular Weight:585.813
Hs Code.:

Synonyms:(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

There total 3 articles about (R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 118949-49-8,139462-27-4
4-benzyl-3-[2-(4-methoxy-benzyloxy)-acetyl]-oxazolidin-2-one

: 681830-17-1
(2R,4R)-2-Methyl-4-triethylsilanyloxy-pentanal

: (R)-4-Benzyl-3-[(4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

: 866148-41-6
(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In toluene; at -50 - -30 ℃; for 2.16667h;
DOI:10.1021/ol051544e

Reference yield:

: 118949-49-8,139462-27-4
4-benzyl-3-[2-(4-methoxy-benzyloxy)-acetyl]-oxazolidin-2-one

: 681830-17-1
(2R,4R)-2-Methyl-4-triethylsilanyloxy-pentanal

: 866148-41-6
(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

Guidance literature:: 4-benzyl-3-[2-(4-methoxy-benzyloxy)-acetyl]-oxazolidin-2-one; With dibutylboron triflate; triethylamine; In toluene; at -50 - -40 ℃; for 2.5h; Inert atmosphere;

(2R,4R)-2-Methyl-4-triethylsilanyloxy-pentanal; In toluene; at -40 ℃; Inert atmosphere;
DOI:10.1002/chem.200802067

Reference yield:

: 118949-49-8,139462-27-4
4-benzyl-3-[2-(4-methoxy-benzyloxy)-acetyl]-oxazolidin-2-one

: 681830-17-1
(2R,4R)-2-Methyl-4-triethylsilanyloxy-pentanal

: 866148-41-6
(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

: 1431561-11-3
C₃₂H₄₇NO₇Si

Guidance literature:: 4-benzyl-3-[2-(4-methoxy-benzyloxy)-acetyl]-oxazolidin-2-one; With di-n-butylboryl trifluoromethanesulfonate; triethylamine; In toluene; at -50 ℃; for 1.5h; Inert atmosphere;

(2R,4R)-2-Methyl-4-triethylsilanyloxy-pentanal; In toluene; at -50 - -30 ℃; for 2.16667h; Overall yield = 72 %; Overall yield = 83 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo3026077