(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

Base Information

Chemical Name:(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester
CAS No.:866148-48-3
Molecular Formula:C₃₀H₅₆O₅SSi₂
Molecular Weight:585.009
Hs Code.:

Synonyms:(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

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Chemical Property of (2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

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Technology Process of (2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

There total 6 articles about (2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 866148-47-2
(R)-4-Benzyl-3-[(2R,3S,4R,6R)-2-(4-methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

: 75-08-1
ethanethiol

: 866148-48-3
(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h;
DOI:10.1021/ol051544e

Reference yield: 95.0%

: C₃₈H₆₁NO₇Si₂

: 75-08-1
ethanethiol

: 866148-48-3
(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

Guidance literature:: ethanethiol; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h; Inert atmosphere;

C₃₈H₆₁NO₇Si₂; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/jo3026077

Reference yield:

: 866148-41-6
(R)-4-Benzyl-3-[(2R,3S,4R,6R)-3-hydroxy-2-(4-methoxy-benzyloxy)-4-methyl-6-triethylsilanyloxy-heptanoyl]-oxazolidin-2-one

: 866148-48-3
(2R,3S,4R,6R)-2-(4-Methoxy-benzyloxy)-4-methyl-3,6-bis-triethylsilanyloxy-heptanethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 2,6-lutidine / tetrahydrofuran / 9 - 20 °C

2: 95 percent / n-BuLi / tetrahydrofuran; hexane / 0.33 h / 0 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1021/ol051544e