2-Aminoadamantane hydrochloride

Base Information

Chemical Name:2-Aminoadamantane hydrochloride
CAS No.:10523-68-9
Molecular Formula:C10H17N.HCl
Molecular Weight:187.713
Hs Code.:29213000
European Community (EC) Number:234-074-2
DSSTox Substance ID:DTXSID60147021
ChEMBL ID:CHEMBL447911
Mol file:10523-68-9.mol

Synonyms:2-aminoadamantane;2-aminoadamantane hydrochloride;2-aminoadamantane sulfate (1:1);2-aminoadamantane sulfate (2:1)

Suppliers and Price of 2-Aminoadamantane hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Adamantanamine Hydrochloride
50mg
$ 55.00

TCI Chemical
2-Adamantanamine Hydrochloride >99.0%(T)
25g
$ 307.00

TCI Chemical
2-Adamantanamine Hydrochloride >99.0%(T)
5g
$ 89.00

SynQuest Laboratories
2-Aminoadamantane hydrochloride
1 g
$ 29.00

SynQuest Laboratories
2-Aminoadamantane hydrochloride
5 g
$ 128.00

SynQuest Laboratories
2-Aminoadamantane hydrochloride
25 g
$ 320.00

Sigma-Aldrich
2-Adamantylamine hydrochloride 99%
25g
$ 323.00

Sigma-Aldrich
2-Adamantylamine hydrochloride 99%
5g
$ 93.00

Matrix Scientific
2-Adamantylamine hydrochloride
1g
$ 15.00

Matrix Scientific
2-Adamantylamine hydrochloride
500mg
$ 10.00

Total 91 raw suppliers

Chemical Property of 2-Aminoadamantane hydrochloride

Chemical Property:

Appearance/Colour:white crystalline powder
Vapor Pressure:0.0831mmHg at 25°C
Melting Point:>300 °C(lit.)
Boiling Point:226.1 °C at 760 mmHg
Flash Point:96.5 °C
PSA：26.02000
LogP:3.27210
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Water Solubility.:soluble
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:187.1127773
Heavy Atom Count:12
Complexity:148

Purity/Quality:

≥99.0% ^*data from raw suppliers

2-Adamantanamine Hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-22
Safety Statements: 26-36-36/37/39-22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2CC3CC1CC(C2)C3N.Cl
Uses 2-Adamantylamine hydrochloride was used to prepare 2-adamantylamide of 2?-(carboxymethoxime)-olivomycin I. The HPLC assay of 2-adamantylamine hydrochloride after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole has been studied. It is also used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. 2-Adamantanamine Hydrochloride can be used to prepare CD73 inhibitors to treat CD73-associated diseases, including cancer and immune-related disorders.

Technology Process of 2-Aminoadamantane hydrochloride

There total 3 articles about 2-Aminoadamantane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 4500-12-3
2-adamantanone oxime

: 700-57-2
1-adamantanol

: 10523-68-9
adamantan-2-amine hydrochloride

Guidance literature:: 2-adamantanone oxime; With NiAl₂; potassium hydroxide; In tetrahydrofuran; water; Reflux;

With hydrogenchloride; In tetrahydrofuran; tert-butyl methyl ether;
DOI:10.1134/S1070428019110162

Reference yield:

: 700-58-3
2-Adamantanone

: 700-57-2
1-adamantanol

: 10523-68-9
adamantan-2-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 20 °C

2: potassium hydroxide; NiAl₂ / water; tetrahydrofuran / Reflux

With hydroxylamine hydrochloride; NiAl₂; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1134/S1070428019110162

Reference yield:

: 281-23-2
adamantane

: 665-66-7,13878-11-0
amantadine hydrochloride

: 10523-68-9
adamantan-2-amine hydrochloride

Guidance literature:: adamantane; With methanol; cerium(III) chloride; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride; In acetonitrile; at 20 ℃; for 10h; Irradiation; Inert atmosphere; Sealed tube;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Reagent/catalyst; Further stages;
DOI:10.1021/jacs.0c00212