4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Base Information

Chemical Name:4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime
CAS No.:1414936-99-4
Molecular Formula:C₂₆H₂₉N₃O₄
Molecular Weight:447.534
Hs Code.:

Synonyms:4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Suppliers and Price of 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

There total 6 articles about 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1414937-27-1
4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde

: 1414936-99-4
4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm3015519

Reference yield:

: 1414937-09-9
methyl 3-(benzyloxy)-4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)prop-1-ynyl)picolinate

: 1414936-99-4
4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on carbon; hydrogen / ethyl acetate / 15 h / 20 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

3: diisobutylaluminium hydride / dichloromethane / 0.17 h / -78 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

5: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.5 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; palladium on carbon; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm3015519

Reference yield:

: 1414937-18-0
methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

: 1414936-99-4
4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinaldehyde oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 15 h / 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / dichloromethane / 0.17 h / -78 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

4: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.5 h / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm3015519