methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

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Chemical Name:methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate
CAS No.:1414937-18-0
Molecular Formula:C₂₇H₃₀N₂O₅
Molecular Weight:462.546
Hs Code.:

Synonyms:methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

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Chemical Property of methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

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Technology Process of methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

There total 3 articles about methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1414937-09-9
methyl 3-(benzyloxy)-4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)prop-1-ynyl)picolinate

: 1414937-18-0
methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

Guidance literature:: With palladium on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm3015519

Reference yield:

: 924041-83-8
6,7-dimethoxy-1-phenyl-2-(prop-2-ynyl)-1,2,3,4-tetrahydroisoquinoline

: 1414937-18-0
methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 15 h / 50 °C / Schlenk technique; Inert atmosphere

2: palladium on carbon; hydrogen / ethyl acetate / 15 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; hydrogen; triethylamine; In tetrahydrofuran; ethyl acetate;
DOI:10.1021/jm3015519

Reference yield:

: phenyltetrahydroisoquinoline

: 1414937-18-0
methyl 4-(3-(6,7-dimethoxy-1-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-3-hydroxypicolinate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 15 h / Reflux

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / tetrahydrofuran / 15 h / 50 °C / Schlenk technique; Inert atmosphere

3: palladium on carbon; hydrogen / ethyl acetate / 15 h / 20 °C / Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1021/jm3015519