3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Base Information

Chemical Name:3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile
CAS No.:1145785-72-3
Molecular Formula:C₂₄H₂₁FN₆O
Molecular Weight:428.469
Hs Code.:

Synonyms:3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Suppliers and Price of 3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

There total 5 articles about 3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1145785-70-1
3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarboxamide

: 1145785-72-3
3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Guidance literature:: With trichlorophosphate; at 20 - 100 ℃;

Reference yield:

: 1244949-16-3
C₁₃H₁₄N₂O₂

: 1145785-72-3
3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane; hydrazine / tetrahydrofuran

2: trichlorophosphate

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; lithium hexamethyldisilazane; hydrazine; trichlorophosphate; In tetrahydrofuran; toluene; 3: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143

Reference yield:

: C₁₆H₁₃N₅O₂

: 1145785-72-3
3-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[4-(4-methyl-1H-imidazol-1-yl)-3-(methyloxy)phenyl]-4-pyridazinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / toluene / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trichlorophosphate; In toluene; 2: Buchwald reaction;
DOI:10.1016/j.bmcl.2011.04.143