1244949-16-3 Usage
Molecular Weight
267.32 g/mol
Functional Groups
Ethanone (ketones)
Phenyl (aromatic ring)
Methoxy (ether)
Imidazol (heterocyclic)
Methyl (alkyl)
Structure
Central ethanone group
Attached phenyl ring
3-methoxy group on the phenyl ring
4-(4-methyl-1H-imidazol-1-yl) substituent on the phenyl ring
Potential Applications
Pharmaceutical industry
Drug development
Chemical Properties
Reactivity with various reagents
Valuable building block for complex organic molecules
Research Interest
Researchers and scientists in various fields
Study of structure and properties
Solubility
Soluble in organic solvents like ethanol, methanol, and acetone
Insoluble in water
Stability
Stable under normal conditions
May decompose under extreme temperatures or with strong acids/bases
Melting Point
Varies depending on the specific compound, but generally has a high melting point due to the presence of aromatic and heterocyclic groups
Boiling Point
Varies depending on the specific compound, but generally has a high boiling point due to the presence of aromatic and heterocyclic groups
Density
Typically less dense than water, but the exact value depends on the specific compound
Optical Properties
May exhibit UV-Vis absorption due to the presence of the phenyl and imidazol groups
May have potential for fluorescence or phosphorescence depending on the specific compound
Synthesis
Can be synthesized through various organic reactions, such as condensation, substitution, or addition reactions involving the appropriate precursors and reagents
Hazards
May be harmful if swallowed, inhaled, or absorbed through the skin
May cause irritation to the eyes, skin, or respiratory system
Proper handling and storage are necessary to minimize risks
Check Digit Verification of cas no
The CAS Registry Mumber 1244949-16-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,9,4 and 9 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1244949-16:
(9*1)+(8*2)+(7*4)+(6*4)+(5*9)+(4*4)+(3*9)+(2*1)+(1*6)=173
173 % 10 = 3
So 1244949-16-3 is a valid CAS Registry Number.
1244949-16-3Relevant academic research and scientific papers
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators
Barnes, Keith D.,Buckle, Ronald N.,Chen, Xinchao,Herr, R. Jason,Johnson, Graham,Lin, Juinn H.,Mayhew, Nicholas J.,Mobley, William C.,Nguyen, Phuong,Paquette, William D.,Rynearson, Kevin D.,Sakwa, Samuel A.,Tanzi, Rudolph E.,Wagner, Steven L.,Yang, Jinhai
, (2020/09/22)
The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaffold provided compounds with improved activity for arresting Aβ42 production as well as improved properties, including solubility. In vivo pharmacokinetic analysis demonstrated that several compounds within the novel series were capable of crossing the BBB and accessing the therapeutic target. Treatment with methoxypyridine-derived compound 64 reduced Aβ42 levels in the plasma of J20 mice, in addition to reducing Aβ42 levels in the plasma and brain of Tg2576 mice.
COMPOUNDS AND USES THEREOF IN MODULATING LEVELS OF VARIOUS AMYLOID BETA PEPTIDE ALLOFORMS
-
, (2012/01/14)
The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)-(C)-(D) or a pharmaceutically acceptable salt or prodrug thereof and methods for using them.
Pyridazine-derived γ-secretase modulators
Wan, Zehong,Hall, Adrian,Jin, Yun,Xiang, Jia-Ning,Yang, Eric,Eatherton, Andrew,Smith, Beverley,Yang, Guang,Yu, Haihua,Wang, Ju,Ye, Liang,Lau, Lit-Fui,Yang, Ting,Mitchell, William,Cai, Wei,Zhang, Xiaomin,Sang, Yingxia,Wang, Yonghui,Tong, Zhaolong,Cheng, Ziqiang,Hussain, Ishrut,Elliott, John D.,Matsuoka, Yasuji
scheme or table, p. 4016 - 4019 (2011/08/06)
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25
