dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester

Base Information

• Chemical Name: dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester
• CAS No.: 1370229-72-3
• Molecular Formula: C₂₂H₃₄N₂O₈S₃
• Molecular Weight: 550.719
• Mol file: 1370229-72-3.mol

Synonyms:dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester

Chemical Property of dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester

There total 4 articles about dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

dithiocarbonic acid S-{2-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-2-oxo-ethyl} ester O-ethyl ester (1370229-62-1) + N-tert-butoxycarbonylprop-2-en-1-amine (78888-18-3) → dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester (1370229-72-3)

Guidance literature:

With dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;

DOI:10.1021/ol3005276

Reference yield:

C11H14ClNO5S (1370229-55-2) → dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester (1370229-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 2 - 3 h / 20 °C / Inert atmosphere

2: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; In ethyl acetate; acetone;

DOI:10.1021/ol3005276

Reference yield:

N-(3,5-dimethoxyphenyl)methanesulfonamide (263854-45-1) → dithiocarbonic acid S-{1-((tert-butoxycarbonylamino)methyl)-4-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-4-oxo-butyl} ester O-ethyl ester (1370229-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 - 0.33 h / 20 °C / Inert atmosphere; Cooling with ice

1.2: 2 - 3 h / Inert atmosphere

2.1: acetone / 2 - 3 h / 20 °C / Inert atmosphere

3.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

With dilauryl peroxide; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;

DOI:10.1021/ol3005276

upstream raw materials:

dithiocarbonic acid S-{2-[methanesulfonyl(3,5-dimethoxyphenyl)amino]-2-oxo-ethyl} ester O-ethyl ester

N-tert-butoxycarbonylprop-2-en-1-amine

C₁₁H₁₄ClNO₅S

N-(3,5-dimethoxyphenyl)methanesulfonamide

Downstream raw materials:

5-(2-acetylamino-4,6-dimethoxyphenyl)piperidin-2-one