ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

Base Information

Chemical Name:ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate
CAS No.:1616280-65-9
Molecular Formula:C₂₀H₂₂IN₃O₆S
Molecular Weight:559.382
Hs Code.:

Synonyms:ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

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Chemical Property of ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

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Technology Process of ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

There total 11 articles about ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₁₇H₁₈IN₃O₄S

: 541-41-3
chloroformic acid ethyl ester

: 1616280-65-9
ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

Guidance literature:: With pyridine; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2016.10.085

Reference yield:

: 1616279-53-8
methyl 4-azido-4-(2-chloro-5-nitrophenyl)butanoate

: 1616280-65-9
ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: tributylphosphine; water / tetrahydrofuran / 0.5 h / 20 °C

2: triethylamine / methanol / 24 h / 50 °C

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

4: potassium carbonate / N,N-dimethyl acetamide / 16 h / 120 °C

5: iron; ammonium chloride / water; isopropyl alcohol / 0.67 h / 60 °C

6: potassium iodide; potassium iodate; hydrogenchloride / water; methanol; 1,4-dioxane / 0.25 h / 50 °C

7: pyridine / 16 h / 20 °C

With pyridine; hydrogenchloride; potassium iodate; tributylphosphine; water; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2016.10.085

Reference yield:

: 1616279-51-6
5-(2-chloro-5-nitrophenyl)dihydrofuran-2(3H)-one

: 1616280-65-9
ethyl (2-iodo-5-(1-methyl-5-oxopyrrolidin-2-yl)-4-((6-(methylsulfonyl)pyridin-3-yl)oxy)phenyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 20 °C

2: diethylazodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

3: tributylphosphine; water / tetrahydrofuran / 0.5 h / 20 °C

4: triethylamine / methanol / 24 h / 50 °C

5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 20 °C

6: potassium carbonate / N,N-dimethyl acetamide / 16 h / 120 °C

7: iron; ammonium chloride / water; isopropyl alcohol / 0.67 h / 60 °C

8: potassium iodide; potassium iodate; hydrogenchloride / water; methanol; 1,4-dioxane / 0.25 h / 50 °C

9: pyridine / 16 h / 20 °C

With pyridine; hydrogenchloride; potassium iodate; tributylphosphine; diphenyl phosphoryl azide; water; iron; sodium hydride; potassium carbonate; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; isopropyl alcohol; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2016.10.085