2-Fluoro-6-hydroxybenzoic acid

Base Information

• Chemical Name: 2-Fluoro-6-hydroxybenzoic acid
• CAS No.: 67531-86-6
• Molecular Formula: C7H5FO3
• Molecular Weight: 156.113
• Hs Code.: 29181990
• Mol file: 67531-86-6.mol

Synonyms:2-Fluoro-6-hydroxybenzoicacid;6-Fluorosalicylic acid;

Chemical Property of 2-Fluoro-6-hydroxybenzoic acid

Chemical Property:

• Appearance/Colour: white to tan powder
• Vapor Pressure: 0.202mmHg at 25°C
• Melting Point: 159-163 °C(lit.)
• Refractive Index: 1.441
• Boiling Point: 291.2 °C at 760 mmHg
• PKA: 2.68±0.25(Predicted)
• Flash Point: 129.9 °C
• PSA: 57.53000
• Density: 1.492 g/cm³
• LogP: 1.22950
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-6-hydoxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-6-hydroxybenzoic acid

There total 9 articles about 2-Fluoro-6-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

2,6-difluorobenzoic acid (385-00-2) → 6-fluorosalicylic acid (67531-86-6)

Guidance literature:

With sodium hydroxide; In water; at 90 - 145 ℃; for 72h;

Reference yield: 93.0%

carbon dioxide (124-38-9,18923-20-1) + 1-fluoro-3-(methoxy-methoxy)benzene (126940-10-1) → 6-fluorosalicylic acid (67531-86-6)

Guidance literature:

1-fluoro-3-(methoxy-methoxy)benzene; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; cyclohexane;

With hydrogenchloride; In water;

DOI:10.1002/ejoc.200400895

Reference yield: 91.0%

2-fluoro-6-(methoxymethoxy)benzoic acid (368422-22-4) → 6-fluorosalicylic acid (67531-86-6)

Guidance literature:

With boron trifluoride diethyl etherate; In methanol; at 25 ℃; for 15h;

DOI:10.1002/1099-0690(200108)2001:15<2911::AID-EJOC2911>3.0.CO;2-W

upstream raw materials:

2-fluoro-6-(methoxymethoxy)benzoic acid

3-(fluorophenyloxy)triisopropylsilane

carbon dioxide

1-fluoro-3-(methoxy-methoxy)benzene

Downstream raw materials:

methyl 2-fluoro-6-methoxybenzoate

6-fluorobenzofuran-7-carboxylic acid

Refernces

• 1、 Luo, Feihua,He, Shuhua,Gou, Quan,Chen, Jinyang,Zhang, mingzhong. "Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids". . . Retrieved 2021/10/06.
• 2、 Baecker, Daniel,Obermoser, Victoria,Kirchner, Elisabeth Anna,Hupfauf, Andrea,Kircher, Brigitte,Gust, Ronald. "Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes". supporting information. p. 15856 - 15868. Retrieved 2019/11/11.