N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

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Chemical Name:N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide
CAS No.:1282614-58-7
Molecular Formula:C₂₆H₃₃FN₄O₃S
Molecular Weight:500.637
Hs Code.:

Synonyms:N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

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Chemical Property of N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

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Technology Process of N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

There total 8 articles about N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 109-83-1
(2-hydroxyethyl)(methyl)amine

: 1282613-00-6
N-butyl-N-(5-(3,5-dimethyl-4-(2-oxoethoxy)phenyl)-1,3,4-thiadiazol-2-yl)-2-fluorobenzamide

: 1282614-58-7
N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

Guidance literature:: (2-hydroxyethyl)(methyl)amine; N-butyl-N-(5-(3,5-dimethyl-4-(2-oxoethoxy)phenyl)-1,3,4-thiadiazol-2-yl)-2-fluorobenzamide; With acetic acid; In methanol; at 20 ℃; for 1h;

With methanol; sodium cyanoborohydride; at 20 ℃;

Reference yield:

: 592-82-5
butyl isothiocyanate

: 1282614-58-7
N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / methanol / 10 - 15 °C

2.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 1.5 h / 20 °C

4.1: osmium(VIII) oxide; 4-methyl-morpholine / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

4.2: 2 h / 20 °C

5.1: acetic acid / methanol / 1 h / 20 °C

5.2: 20 °C

With 4-methyl-morpholine; osmium(VIII) oxide; sodium hydride; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; tert-butyl alcohol;

Reference yield:

: 100191-87-5
4-(allyloxy)-3,5-dimethylbenzonitrile

: 1282614-58-7
N-butyl-2-fluoro-N-[5-(4-{2-[(2-hydroxyethyl)(methyl)amino]ethoxy}-3,5-dimethylphenyl)-1,3,4-thiadiazol-2-yl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / ethanol / 20 - 110 °C / Sealed

1.2: pH 1

2.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 1.5 h / 20 °C

4.1: osmium(VIII) oxide; 4-methyl-morpholine / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

4.2: 2 h / 20 °C

5.1: acetic acid / methanol / 1 h / 20 °C

5.2: 20 °C

With 4-methyl-morpholine; osmium(VIII) oxide; water; sodium hydride; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; tert-butyl alcohol;