methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

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Chemical Name:methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate
CAS No.:1316673-78-5
Molecular Formula:C₂₉H₄₇NO₅Si
Molecular Weight:517.781
Hs Code.:

Synonyms:methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

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Chemical Property of methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

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Technology Process of methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

There total 4 articles about methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1345730-73-5
N-benzylidene-1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-amine N-oxide

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1316673-78-5
methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

Guidance literature:: tris-iso-propylsilyl acetylene; With diethylzinc; In hexane; benzene; at 0 ℃; for 0.0833333h; Molecular sieve;

N-benzylidene-1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-amine N-oxide; In hexane; benzene; at 0 - 20 ℃; optical yield given as %de;
DOI:10.1021/ol201629n

Reference yield: 90.0%

: 1345730-73-5
N-benzylidene-1-methoxy-1-oxo-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propan-2-amine N-oxide

: C₁₃H₂₆SiZn

: 1316673-78-5
methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

Guidance literature:: In benzene; at 0 - 20 ℃; for 2h; diastereoselective reaction;
DOI:10.1002/tcr.201100024

Reference yield:

: 5660-63-9
4,4,5,5-tetramethyl-1,3-dioxolane

: 1316673-78-5
methyl 2-(hydroxy(1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-yl)amino)-2-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butylhydroperoxide; 1,10-Phenanthroline; Copper(I); benzoate; sodium hydrogencarbonate / decane; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2.1: diethylzinc / hexane; benzene / 0.08 h / 0 °C / Molecular sieve

2.2: 0 - 20 °C

With tert.-butylhydroperoxide; 1,10-Phenanthroline; diethylzinc; Copper(I); benzoate; sodium hydrogencarbonate; In decane; hexane; dimethyl sulfoxide; benzene;
DOI:10.1021/ol201629n