1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Base Information

• Chemical Name: 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one
• CAS No.: 543745-11-5
• Molecular Formula: C₂₀H₁₁F₄IN₄O
• Molecular Weight: 526.232

Synonyms:1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Chemical Property of 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

There total 10 articles about 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-iodophenyl)-3-(4-morpholinyl)-4-(trifluoroacetyl)-5,6-dihydro-2(1H)-pyridinone (536759-87-2) + 2-fluoro-5-hydrazinobenzonitrile hydrochloride (280120-91-4) → 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one (543745-11-5)

Guidance literature:

With hydrogenchloride; acetic acid; In methanol;

Reference yield:

1-(2-oxopiperidin-1-yl)-4-iodobenzene (385425-15-0) → 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one (543745-11-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: phosphorus pentachloride / CHCl₃ / Heating

2.1: 140 °C

3.1: DMAP / CH₂Cl₂

3.2: aq. HCl / diethyl ether

4.1: methanol

With dmap; phosphorus pentachloride; In methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2006.02.069

Reference yield:

5-bromo-pentanoic acid-(4-iodophenyl)amide → 1-(3-cyano-4-fluoro)phenyl-3-trifluoromethyl-6-(4-iodo)phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one (543745-11-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium tert-butoxide

2.1: phosphorus pentachloride / CHCl₃ / Heating

3.1: 140 °C

4.1: DMAP / CH₂Cl₂

4.2: aq. HCl / diethyl ether

5.1: methanol

With dmap; phosphorus pentachloride; potassium tert-butylate; In methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2006.02.069

upstream raw materials:

1-(4-iodophenyl)-4-(2,2,2-trifluoroacetyl)-piperidine-2,3-dione

2-fluoro-5-hydrazinobenzonitrile

1-(2-oxopiperidin-1-yl)-4-iodobenzene

3,3-dichloro-1-(4-iodophenyl)-piperidin-2-one

Downstream raw materials:

1-(3-Cyano-4-fluoro)phenyl-3-trifluoromethyl-6-[4-(2-formyl)phenyl]phenyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

1-(3-amino-benzo[d]isoxazol-5-yl)-6-[2'-(3-hydroxy-pyrrolidin-1-ylmethyl)-biphenyl-4-yl]-3-trifluoromethyl-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one

BMS-740808

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