tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Base Information

Chemical Name:tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate
CAS No.:1386981-69-6
Molecular Formula:C₃₁H₃₃ClN₆O₆
Molecular Weight:621.093
Hs Code.:

Synonyms:tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Chemical Property of tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

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Technology Process of tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

There total 4 articles about tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.4%

: 943321-68-4
(±)-tert-butyl N-(3-amino-3-phenyl-propyl)carbamate

: 1386981-67-4
4-Chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)-benzoic acid

: 1386981-69-6
tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 7.5h;

Reference yield:

: 5053-63-4
3-amino-1-phenylpropan-1-ol

: 1386981-69-6
tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: hydrazine hydrate / tetrahydrofuran; methanol / 6 h / 65 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 7.5 h / 20 °C

With hydrazine hydrate; triethylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 614-16-4
Benzoylacetonitrile

: 1386981-69-6
tert-butyl 3-(4-chloro-3-(2-methoxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine / tetrahydrofuran / 0 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 6 h / 65 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 7.5 h / 20 °C

With lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;