N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

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Chemical Name:N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide
CAS No.:1419601-38-9
Molecular Formula:C₂₂H₂₃ClF₃N₅O₂
Molecular Weight:481.905
Hs Code.:

Synonyms:N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

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Chemical Property of N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

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Technology Process of N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

There total 10 articles about N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1254713-79-5
(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

: 1419604-83-3
2-(6-((2-methoxyethyl)amino)pyridin-3-yl)propanoic acid

: 1419601-38-9
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1419601-38-9
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 5 h / Reflux

2: N-chloro-succinimide / N,N-dimethyl-formamide / 3.25 h / 23 °C

3: triethylamine / toluene / 20 h / 80 °C

4: hydrogen; ammonia / methanol / 80 °C / 7500.75 Torr

5: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 23 °C

With N-chloro-succinimide; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 866629-20-1
2-(6-chloropyridin-3-yl)propanenitrile

: 1419601-38-9
N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(6-(2-methoxyethylamino)pyridin-3-yl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dimethyl sulfoxide / 16 h / 100 °C

2.1: chloro-trimethyl-silane / 5 h / 60 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 2 h / 60 °C

3.2: pH Ca_. 4

4.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 h / 23 °C

With chloro-trimethyl-silane; lithium hydroxide monohydrate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;