1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

Base Information

Chemical Name:1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine
CAS No.:951744-45-9
Molecular Formula:C₃₇H₄₂N₂O₆
Molecular Weight:610.75
Hs Code.:

Synonyms:1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

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Chemical Property of 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

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Technology Process of 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

There total 10 articles about 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 951744-44-8
1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1H-pyrrol-2-yl)piperidine

: 951744-45-9
1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

Reference yield:

: 498-94-2
isonipecotic acid

: 951744-45-9
1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / water / 20 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

6.1: dimethyl sulfoxide / 4.5 h / 140 °C

7.1: ammonium acetate; acetic acid / 4 h / 90 °C

8.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With n-butyllithium; oxalyl dichloride; ammonium acetate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 951744-45-9
1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1-tert-butoxycarbonylmethylpyrrol-2-yl)piperidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 1.5 h / -78 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

5.1: dimethyl sulfoxide / 4.5 h / 140 °C

6.1: ammonium acetate; acetic acid / 4 h / 90 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

With n-butyllithium; oxalyl dichloride; ammonium acetate; sodium hydride; potassium carbonate; acetic acid; diisopropylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;