Technology Process of 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1H-pyrrol-2-yl)piperidine
There total 10 articles about 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)-1H-pyrrol-2-yl)piperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-benzyloxycarbonyl-4-(3,4-bis(4-methoxyphenyl)-1,4-dioxobutyl)piperidine;
With
ammonium acetate; acetic acid;
at 90 ℃;
for 4h;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / water / 20 h / 20 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C
3.2: 1.5 h / -78 °C
4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C
6.1: dimethyl sulfoxide / 4.5 h / 140 °C
7.1: ammonium acetate; acetic acid / 4 h / 90 °C
With
n-butyllithium; oxalyl dichloride; ammonium acetate; sodium hydrogencarbonate; potassium carbonate; acetic acid; diisopropylamine; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C
2.2: 1.5 h / -78 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C
5.1: dimethyl sulfoxide / 4.5 h / 140 °C
6.1: ammonium acetate; acetic acid / 4 h / 90 °C
With
n-butyllithium; oxalyl dichloride; ammonium acetate; potassium carbonate; acetic acid; diisopropylamine; trifluoroacetic acid;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
