methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Base Information

Chemical Name:methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate
CAS No.:538335-91-0
Molecular Formula:C₂₆H₂₉N₅O₅
Molecular Weight:491.547
Hs Code.:

Synonyms:methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

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Chemical Property of methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Chemical Property:

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Technology Process of methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

There total 7 articles about methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210962-09-7
1-(pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride

: 3-[4-cyano-2-(2-aminoethoxy)phenyl]-2-acetamidoacrylic acid methyl ester hydrochloride

: 538335-91-0
methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm020485x

Reference yield:

: 210962-75-7
3-hydroxy-4-iodobenzonitrile

: 538335-91-0
methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

2: 60 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating

3: 78 percent / HCl / dioxane

4: triethylamine; bromotripyrrolidinophosphonium hexafluorophosphate / dimethylformamide / 20 °C

With hydrogenchloride; palladium diacetate; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1021/jm020485x

Reference yield:

: carbonic acid 5-cyano-2-iodo-phenyl ester ethyl ester

: 538335-91-0
methyl 2-acetamido-3-[2-[2-[1-(pyridin-4-yl)piperidine-4-carbonylamino]ethoxy]-4-cyanophenyl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: 9.29 g / aq. NaOH / methanol; tetrahydrofuran / 4 h

2: 81 percent / K₂CO₃; KI / dimethylformamide / 60 °C

3: 60 percent / triethylamine; tri-o-tolylphosphine; Pd(OAc)2 / acetonitrile / Heating

4: 78 percent / HCl / dioxane

5: triethylamine; bromotripyrrolidinophosphonium hexafluorophosphate / dimethylformamide / 20 °C

With hydrogenchloride; palladium diacetate; sodium hydroxide; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; potassium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile; 3: Heck reaction;
DOI:10.1021/jm020485x