(R)-2-(1-azidoethyl)-6-phenylpyridine

Base Information

• Chemical Name: (R)-2-(1-azidoethyl)-6-phenylpyridine
• CAS No.: 162085-33-8
• Molecular Formula: C₁₃H₁₂N₄
• Molecular Weight: 224.265
• Mol file: 162085-33-8.mol

Synonyms:(R)-2-(1-azidoethyl)-6-phenylpyridine

Chemical Property of (R)-2-(1-azidoethyl)-6-phenylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (R)-2-(1-azidoethyl)-6-phenylpyridine

There total 2 articles about (R)-2-(1-azidoethyl)-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(S)-2-(1-hydroxyethyl)-6-phenylpyridine (162238-28-0) → (R)-2-(1-azidoethyl)-6-phenylpyridine (162085-33-8)

Guidance literature:

With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 0 - 50 ℃; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/jo900271x

Reference yield:

Methanesulfonic acid (S)-1-(6-phenyl-pyridin-2-yl)-ethyl ester (162085-32-7) → (R)-2-(1-azidoethyl)-6-phenylpyridine (162085-33-8)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 24h; Yield given; Ambient temperature;

DOI:10.1016/S0957-4166(00)86272-2

Reference yield: 95.0%

(R)-2-(1-azidoethyl)-6-phenylpyridine (162085-33-8) → (R)-1-(6-phenylpyridin-2-yl)ethanamine (162085-34-9)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; optical yield given as %ee; Reflux;

DOI:10.1021/jo900271x

upstream raw materials:

Methanesulfonic acid (S)-1-(6-phenyl-pyridin-2-yl)-ethyl ester

(S)-2-(1-hydroxyethyl)-6-phenylpyridine

Downstream raw materials:

(R)-1-(6-phenylpyridin-2-yl)ethanamine