(S)-2-(1-hydroxyethyl)-6-phenylpyridine

Base Information

• Chemical Name: (S)-2-(1-hydroxyethyl)-6-phenylpyridine
• CAS No.: 162238-28-0
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.252
• Mol file: 162238-28-0.mol

Synonyms:(S)-2-(1-hydroxyethyl)-6-phenylpyridine

Chemical Property of (S)-2-(1-hydroxyethyl)-6-phenylpyridine

Chemical Property:

• Boiling Point: 348.1±30.0 °C(Predicted)
• Density: 1.113±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1-hydroxyethyl)-6-phenylpyridine

There total 3 articles about (S)-2-(1-hydroxyethyl)-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl(2-phenylpyridin-6-yl)-methanone (59576-29-3) → (S)-2-(1-hydroxyethyl)-6-phenylpyridine (162238-28-0)

Guidance literature:

With Saccharomyces cerevisiae; D-glucose; at 20 ℃; pH=7.4; optical yield given as %ee; aq. phosphate buffer;

DOI:10.1021/jo900271x

Reference yield: 45.0%

vinyl acetate (108-05-4,9003-20-7) + α-methyl-6-phenyl-2-pyridinemethanol (139163-61-4) → (R)-2-(1-hydroxyethyl)-6-phenylpyridine (138983-03-6) + (S)-2-(1-hydroxyethyl)-6-phenylpyridine (162238-28-0) + (R)-2-(1-acetoxyethyl)-6-phenylpyridine (204244-63-3)

Guidance literature:

With Candida antarctica lipase B; In tert-butyl methyl ether; at 20 ℃; optical yield given as %ee; Resolution of racemate; Inert atmosphere; Enzymatic reaction;

DOI:10.1021/jo900271x

Reference yield: 45.0%

vinyl acetate (108-05-4,9003-20-7) + α-methyl-6-phenyl-2-pyridinemethanol (139163-61-4) → (S)-2-(1-hydroxyethyl)-6-phenylpyridine (162238-28-0) + (R)-2-(1-acetoxyethyl)-6-phenylpyridine (204244-63-3)

Guidance literature:

With 4 A molecular sieve; In di-isopropyl ether; for 7h; Ambient temperature; Candida antarctica lipase presence;

DOI:10.1021/jo971521g

upstream raw materials:

vinyl acetate

α-methyl-6-phenyl-2-pyridinemethanol

methyl(2-phenylpyridin-6-yl)-methanone

Downstream raw materials:

C₃₁H₃₆NO₃PSi₂

(R)-2-(1-azidoethyl)-6-phenylpyridine

(R)-1-(6-phenylpyridin-2-yl)ethanamine

Methanesulfonic acid (S)-1-(6-phenyl-pyridin-2-yl)-ethyl ester