5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Base Information

Chemical Name:5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
CAS No.:61727-33-1
Molecular Formula:C6H5 Cl N2 O2 S
Molecular Weight:204.637
Hs Code.:2933599090
European Community (EC) Number:626-210-8
DSSTox Substance ID:DTXSID10352401
Nikkaji Number:J1.708.856D
Wikidata:Q72455412
ChEMBL ID:CHEMBL1416114

Synonyms:5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid;61727-33-1;4-pyrimidinecarboxylic acid, 5-chloro-2-(methylthio)-;5-chloro-2-(methylsulfanyl)pyrimidine-4-carboxylic acid;MFCD00173907;5-chloro-2-methylsulfanylpyrimidine-4-carboxylic acid;5-Chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid;5-chloro-2-(methylthio)-4-pyrimidinecarboxylic acid;C6H5ClN2O2S;Maybridge1_002267;4-Carboxy-5-chloro-2-(methylthio)pyrimidine;MLS000551292;SCHEMBL1533879;CHEMBL1416114;HMS547P01;DTXSID10352401;SEPCYCDQJZTPHO-UHFFFAOYSA-N;HMS2171M16;HMS3318F17;CCG-50437;STK702749;AKOS000268385;AC-7352;CS-W002473;PS-4957;SB60699;SMR000145218;SY005865;AM20100511;BB 0258216;C2549;FT-0600991;EN300-25395;A833396;5-Chloro-2-methylthio-4-pyrimidine carboxylic acid;J-517282;SR-01000639814-1;4-Pyrimidinecarboxylic acid,5-chloro-2-(methylthio)-;5-Chloro-2-(methylthio)pyrimidine-4 -carboxylic acid;BRD-K16960866-001-08-8;Z210803658;5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, 95%

Suppliers and Price of 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Chloro-2-(methylthio)-4-pyrimidinecarboxylicAcid
1g
$ 120.00

TCI Chemical
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic Acid >97.0%(GC)(T)
5g
$ 103.00

TCI Chemical
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic Acid >97.0%(GC)(T)
1g
$ 36.00

SynQuest Laboratories
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 98%
1 g
$ 21.00

Sigma-Aldrich
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 95%
1g
$ 50.00

Matrix Scientific
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 95+%
25g
$ 97.00

Matrix Scientific
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 95+%
5g
$ 26.00

Matrix Scientific
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 95+%
100g
$ 324.00

Crysdot
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic Acid 98%
100g
$ 320.00

Chem-Impex
5-Chloro-2-(methylthio)pyrimidine-4-carboxylicAcid,≥97%(GC) ≥97%(GC)
5G
$ 110.12

Total 50 raw suppliers

Chemical Property of 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Chemical Property:

Vapor Pressure:5.4E-07mmHg at 25°C
Melting Point:204-205 ºC
Boiling Point:396.4°C at 760 mmHg
PKA:1.20±0.25(Predicted)
Flash Point:193.5°C
PSA：88.38000
Density:1.59g/cm³
LogP:1.55010
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:soluble in Methanol
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:203.9760263
Heavy Atom Count:12
Complexity:181

Purity/Quality:

99%, ^*data from raw suppliers

5-Chloro-2-(methylthio)-4-pyrimidinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36-37/38-36/37/38
Safety Statements: 26-36/37-37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=NC=C(C(=N1)C(=O)O)Cl
Uses 5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic acid is a synthetic intermediate in the preparation of GSK3β inhibitors and non-nucleoside reverse transcriptase inhibitors for treating HIV infection.

Technology Process of 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

There total 4 articles about 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.9%