tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Base Information

Chemical Name:tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate
CAS No.:1218925-88-2
Molecular Formula:C₁₇H₂₀N₂O₅
Molecular Weight:332.356
Hs Code.:

Synonyms:tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

There total 4 articles about tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 102-96-5
(2-nitroethenyl)benzene

: 141293-14-3
N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

: 1218925-88-2
tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With C₃₄H₂₀N₂Ni₂O₄; In 1,4-dioxane; at 20 - 50 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja1002636

Reference yield:

: 102-96-5
(2-nitroethenyl)benzene

: 141293-14-3
N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

: 1218925-88-2
tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

: 1397294-17-5
tert-butyl (2R)-2-((1R)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With C₂₄H₃₄N₂O₂; In triflourotoluene; at 25 ℃; for 49h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2ob25832c

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1218925-88-2
tert-butyl (2S)-2-((1S)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

: 1397294-17-5
tert-butyl (2R)-2-((1R)-2-nitro-1-phenylethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / acetonitrile / 2 h / 20 °C / Inert atmosphere

2: C₂₄H₃₄N₂O₂ / triflourotoluene / 49 h / 25 °C / Inert atmosphere

With dmap; C₂₄H₃₄N₂O₂; In triflourotoluene; acetonitrile; 2: Michael addition;
DOI:10.1039/c2ob25832c