4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

Base Information

Chemical Name:4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one
CAS No.:1215109-63-9
Molecular Formula:C₁₅H₁₉F₃N₂O₃S
Molecular Weight:364.389
Hs Code.:

Synonyms:4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

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Chemical Property of 4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

Chemical Property:

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Technology Process of 4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

There total 6 articles about 4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1215111-58-2
1-(2-aminobenzyl)-4,4-dimethylpiperidin-2-one

: 1215109-63-9
4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 3958-60-9
2-nitrophenylmethyl bromide

: 1215109-63-9
4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / 2 h / 0 - 20 °C

4: iron; ammonium chloride / ethanol; water / 1 h / Reflux

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With triethylsilane; sodium tetrahydroborate; iron; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1215111-85-5
4,4-dimethyl-1-(2-nitrobenzyl)piperidine-2,6-dione

: 1215109-63-9
4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C

2: triethylsilane; trifluoroacetic acid / 2 h / 0 - 20 °C

3: iron; ammonium chloride / ethanol; water / 1 h / Reflux

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With triethylsilane; sodium tetrahydroborate; iron; ammonium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;