1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

Base Information

Chemical Name:1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one
CAS No.:1215109-68-4
Molecular Formula:C₁₉H₂₃F₃N₂O₄S
Molecular Weight:432.464
Hs Code.:

Synonyms:1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

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Chemical Property of 1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

Chemical Property:

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Technology Process of 1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

There total 7 articles about 1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215109-63-9
4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1215109-68-4
1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

Guidance literature:: 4,4-dimethyl-1-(2-trifluoromethanesulfonylaminobenzyl)piperidin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Cooling with ice;

cyclopropanecarboxylic acid chloride; In tetrahydrofuran;

Reference yield:

: 3958-60-9
2-nitrophenylmethyl bromide

: 1215109-68-4
1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2: sodium tetrahydroborate / tetrahydrofuran; water / 1 h / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / 2 h / 0 - 20 °C

4: iron; ammonium chloride / ethanol; water / 1 h / Reflux

5: triethylamine / dichloromethane / 1 h / 0 - 20 °C

6: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with ice

With triethylsilane; sodium tetrahydroborate; iron; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1215111-58-2
1-(2-aminobenzyl)-4,4-dimethylpiperidin-2-one

: 1215109-68-4
1-[2-(N-cyclopropylcarbonyl-N-trifluoromethanesulfonyl)aminobenzyl]-4,4-dimethylpiperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Cooling with ice

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;