5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

Base Information

Chemical Name:5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine
CAS No.:1037793-58-0
Molecular Formula:C₂₂H₂₄N₈OS
Molecular Weight:448.552
Hs Code.:

Synonyms:5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

Suppliers and Price of 5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

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Technology Process of 5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

There total 5 articles about 5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044136-64-2
3-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidine hydrochloride

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1037793-58-0
5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

Reference yield:

: C₁₆H₁₈N₆OS*(x)ClH

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1037793-58-0
5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

Reference yield:

: 1044136-63-1
3-(4-chloromethylthiazol-2-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1037793-58-0
5-ethyl-2-{3-[4-(4-tetrazol-1-ylphenoxymethyl)thiazol-2-yl]piperidin-1-yl}pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; potassium iodide / acetonitrile / 4 h / Reflux

2: hydrogenchloride / methanol; 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 4 h / 90 °C

With hydrogenchloride; sodium hydrogencarbonate; caesium carbonate; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;