66358-23-4

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Imidazo[1,2-a]pyridin-5-ylamine is used as a versatile building block in organic synthesis for the development of new drugs and pharmaceutical compounds. Its unique fused ring structure allows for the creation of various derivatives with improved properties for specific applications in medicinal chemistry.
Used in Metabolic Disorders and Cancer Treatment:
Imidazo[1,2-a]pyridin-5-ylamine is used as a potent inhibitor of the enzyme adenosine 5'-monophosphate-activated protein kinase (AMPK), which is involved in cellular energy homeostasis. This makes it a promising candidate for the development of new drugs targeting metabolic disorders and cancer, as it can help regulate cellular energy balance and potentially inhibit the growth and progression of cancer cells.
Used in Medicinal Chemistry:
Imidazo[1,2-a]pyridin-5-ylamine is used as a valuable chemical compound in medicinal chemistry for the synthesis of new derivatives with improved properties. Its chemical structure can be modified to enhance the efficacy and selectivity of drugs, making it an essential component in the development of innovative therapeutic agents for various diseases and conditions.

InChI:InChI=1/C7H7N3/c8-6-2-1-3-7-9-4-5-10(6)7/h1-5H,8H2

Upstream product

• 107-20-0 2-chloroethanal 
• 141-86-6 2.6-diaminopyridine 

Downstream Products

• 887576-32-1 imidazo[1,2-a]pyridin-5-ol 
• 166176-53-0 5-tert-butoxycarbonylaminoimidazo[1,2-a]pyridine 
• 1230020-10-6 4-[3-(4-chloro-phenoxy)-benzyl]-piperazine-1-carboxylic acid imidazo[1,2-a]pyridin-5-ylamide 

Relevant academic research and scientific papers

HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE

Certain heteroaryl-substituted piperidinyl and piperazinyl urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, insulin resistance, diabetes, osteoporosis, and movement disorders (e.g., multiple sclerosis).

NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A'): wherein X is a carbon and X is an oxygen, a sulfur or - NR -,or formula (A"): wherein X is a nitrogen and R is an optionally substituted hydrocarbyl, Ris an amino substituted by two optionally substituted hydrocarbyl groups, Ris an phenyl, Y is CR or a nitrogen, Y is CRor a nitrogen and Yis CRor a nitrogen, provided that one or less of Y, Y, and Y is nitrogen, W is a bond, -(CH2)n-, and Z is a bond, -NR -,etc.; or a salt thereof or a prodrug thereof.