3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

Base Information

Chemical Name:3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine
CAS No.:1338815-23-8
Molecular Formula:C₂₄H₄₁N₃O₂Si
Molecular Weight:431.694
Hs Code.:

Synonyms:3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

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Chemical Property of 3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

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Technology Process of 3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

There total 4 articles about 3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 1337931-73-3
(4-(5-amino-3-(tert-butyl)-1H-pyrazol-1-yl)-2-methoxyphenyl)methanol

: 1338815-23-8
3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; at 20 ℃; for 139h; Inert atmosphere;

Reference yield:

: 2486-80-8
4-amino-2-methoxybenzoic acid

: 1338815-23-8
3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 5.08 h / 0 °C

1.2: 64 h / 0 - 20 °C

2.1: hydrogenchloride / ethanol; water / 28 h / Reflux

2.2: 20 h / 20 °C

3.1: diborane / tetrahydrofuran / 46.08 h / 0 - 20 °C / Inert atmosphere

3.2: 0.17 h / 20 °C

4.1: 1H-imidazole / tetrahydrofuran / 139 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; diborane; sodium nitrite; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1338815-21-6
2-methoxy-4-hydrazinylbenzoic acid hydrochloride

: 1338815-23-8
3-tert-butyl-1-(3-methoxy-4-((triisopropylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 28 h / Reflux

1.2: 20 h / 20 °C

2.1: diborane / tetrahydrofuran / 46.08 h / 0 - 20 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: 1H-imidazole / tetrahydrofuran / 139 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; diborane; In tetrahydrofuran; ethanol; water;