(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

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Chemical Name:(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid
CAS No.:174602-87-0
Molecular Formula:C₄₇H₇₀N₆O₉
Molecular Weight:863.108
Hs Code.:

(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

Synonyms:(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

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Chemical Property of (S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

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Technology Process of (S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

There total 12 articles about (S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-16-7,35264-07-4,55721-65-8,55780-90-0,116194-21-9
Boc-L-aIle-OH

: 174602-87-0
(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine (NMM)

3: 50percent TFA / CH₂Cl₂

4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (DEC), 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOOBt)

6: H₂ / 10percent Pd/C

With 4-methyl-morpholine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(96)01199-9

Reference yield:

: C₁₆H₂₉NO₅

: 174602-87-0
(S)-2-[(S)-2-({(2S,3R)-2-[((S)-1-{(S)-2-[((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-methyl-amino]-3-phenyl-propionyl}-pyrrolidine-2-carbonyl)-amino]-3-methyl-pentanoyl}-methyl-amino)-3-methyl-butyrylamino]-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

2: 50percent TFA / CH₂Cl₂

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (DEC), 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine (HOOBt)

5: H₂ / 10percent Pd/C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/0040-4039(96)01199-9