2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Base Information

Chemical Name:2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine
CAS No.:161599-46-8
Molecular Formula:C13H16FN3O6
Molecular Weight:329.285
Hs Code.:29389090
European Community (EC) Number:605-260-4
Mol file:161599-46-8.mol

Synonyms:5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine;

Suppliers and Price of 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
98.00%
100G
$ 110.00

AccelPharmtech
98.00%
250G
$ 160.00

AccelPharmtech
98.00%
500G
$ 220.00

AK Scientific
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
25g
$ 260.00

AK Scientific
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
100g
$ 850.00

AK Scientific
2',3'-Di-O-acetyl-5'-deoxy-5-fluorocytidine
1g
$ 20.00

Ambeed
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine 95%
5g
$ 32.00

Ambeed
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine 95%
250mg
$ 7.00

Ambeed
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine 95%
1g
$ 11.00

Ambeed
5'-Deoxy-2',3'-di-O-acetyl-5-fluorocytidine 95%
10g
$ 46.00

Total 237 raw suppliers

Chemical Property of 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

Chemical Property:

Appearance/Colour:WHITE
Melting Point:196-198?C
Boiling Point:427.4 °C at 760 mmHg
PKA:2.49±0.10(Predicted)
Flash Point:212.3 °C
PSA：122.74000
Density:1.57 g/cm³
LogP:0.32650
Storage Temp.:-20°C Freezer
Solubility.:soluble in Methanol
XLogP3:-0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:329.10231340
Heavy Atom Count:23
Complexity:605

Purity/Quality:

99% ^*data from raw suppliers

98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C(C(C(O1)N2C=C(C(=NC2=O)N)F)OC(=O)C)OC(=O)C
Uses Capecitabine intermediate A metabolite of Capecitabine. A metabolite of Capecitabine. Capecitabine Diacetyl Amino Impurity (USP).

Technology Process of 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine

There total 30 articles about 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

: 1054449-33-0
2',3'-di-O-ethanoyl-5-fluorocytidine

: 161599-46-8,2230479-30-6
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: With triethylsilane; trifluoroacetic acid; In chloroform; at -10 - -5 ℃; for 3h; Solvent; Temperature; Inert atmosphere;

Reference yield: 88.6%

: 2022-85-7
Flucytosine

: 27821-07-4,27930-18-3,37076-71-4,62211-93-2,63903-44-6,76497-54-6
1,2,3-tri-O-acetyl-5-deoxy-β-D-ribofuranose

: 161599-46-8,2230479-30-6
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 10 - 20 ℃; for 4h; Solvent;

Reference yield: 86.0%

: 110022-91-8
di-O-acetyl-5-deoxy-ξ-D-ribofuranosyl chloride

: 111878-21-8
2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine

: 161599-46-8,2230479-30-6
(2R,3R,4R,5R)-2-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-5-methyl-tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: di-O-acetyl-5-deoxy-ξ-D-ribofuranosyl chloride; 2-trimethylsilyloxy-4-trimethylsilylamino-5-fluoropyrimidine; In 1,2-dichloro-ethane; for 4h; Inert atmosphere; Schlenk technique; Reflux;

With water; Inert atmosphere; Schlenk technique;
DOI:10.3390/molecules22010084