2-Chloro-4-fluorobenzylamine

Base Information

• Chemical Name: 2-Chloro-4-fluorobenzylamine
• CAS No.: 15205-11-5
• Molecular Formula: C7H7ClFN
• Molecular Weight: 159.591
• Hs Code.: 2921499090
• Mol file: 15205-11-5.mol

Synonyms:Benzylamine,2-chloro-4-fluoro- (8CI);(2-Chloro-4-fluorophenyl)methanamine;2-Chloro-4-fluorobenzylamine;[(2-Chloro-4-fluorophenyl)methyl]amine;

Chemical Property of 2-Chloro-4-fluorobenzylamine

Chemical Property:

• Appearance/Colour: clear colorless to light yellow liquid
• Melting Point: 172-173 °C(Solv: N,N-dimethylformamide (68-12-2))
• Refractive Index: 1.535
• Boiling Point: 216.199 °C at 760 mmHg
• PKA: 8.46±0.10(Predicted)
• Flash Point: 84.554 °C
• PSA: 26.02000
• Density: 1.271 g/cm³
• LogP: 2.63810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-fluorobenzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-fluorobenzylamine

There total 2 articles about 2-Chloro-4-fluorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-fluorobenzylbromide (45767-66-6) → 2-chloro-4-fluorobenzylamine (15205-11-5)

Guidance literature:

With ammonia; In methanol; at 50 ℃; for 2h; Inert atmosphere;

Reference yield:

→ 2-chloro-4-fluorobenzylamine (15205-11-5)

Guidance literature:

Reference yield: 100.0%

(R)-tetrahydro-5-oxo-2-furancarboxylic acid (53558-93-3) + 2-chloro-4-fluorobenzylamine (15205-11-5) → N-(2-chloro-4-fluorobenzyl)-5-oxotetrahydrofuran-2-carboxamide

Guidance literature:

(R)-tetrahydro-5-oxo-2-furancarboxylic acid; With thionyl chloride; for 10h; Reflux;

2-chloro-4-fluorobenzylamine; With triethylamine; In dichloromethane; at 0 ℃; for 3h;

upstream raw materials:

2-chloro-4-fluorobenzylbromide

Downstream raw materials:

{2-[3-(2-chloro-4-fluoro-benzyl)-5-(2-fluoro-phenyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

N-[(2-chloro-4-fluorophenyl)methyl]-5-oxo-1-(phenylmethyl)-prolinamide

N-[(2-chloro-4-fluorophenyl)methyl]-1-(1-methylethyl)-5-oxo-prolinamide

N-[(2-chloro-4-fluorophenyl)methyl]-1-ethyl-5-oxo-L-prolinamide