6-methyl-2-benzylquinoline

Base Information

• Chemical Name: 6-methyl-2-benzylquinoline
• CAS No.: 1139921-57-5
• Molecular Formula: C₁₇H₁₅N
• Molecular Weight: 233.313
• Mol file: 1139921-57-5.mol

Synonyms:6-methyl-2-benzylquinoline

Chemical Property of 6-methyl-2-benzylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 6-methyl-2-benzylquinoline

There total 12 articles about 6-methyl-2-benzylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-phenyl-3-buten-2-ol (6052-66-0,112370-40-8,123877-73-6) + p-toluidine (106-49-0,12221-03-3) → 6-methyl-2-benzylquinoline (1139921-57-5)

Guidance literature:

p-toluidine; With acetic anhydride; In tetrahydrofuran; Inert atmosphere;

1-phenyl-3-buten-2-ol; With silver hexafluoroantimonate; [RhCl₂(p-cymene)]2; copper(II) acetate monohydrate; In tetrahydrofuran; at 120 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.7b00715

Reference yield: 77.0%

bromobenzene (108-86-1,52753-63-6) + 1-(6-methylquinolin-2-yl)-2-isopropyl-3-methylbutan-2-ol (1139921-49-5) → 6-methyl-2-benzylquinoline (1139921-57-5)

Guidance literature:

With palladium(II) trifluoroacetate; caesium carbonate; triphenylphosphine; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1021/jo900073z

Reference yield: 73.0%

6-methylquinoline-N-oxide (4053-42-3) + benzyltrimethylsilane (770-09-2) → 6-methyl-2-benzylquinoline (1139921-57-5)

Guidance literature:

With triethylsilane; tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01141

upstream raw materials:

bromobenzene

1-(6-methylquinolin-2-yl)-2-isopropyl-3-methylbutan-2-ol

1-phenyl-3-buten-2-ol

p-toluidine