(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Base Information

Chemical Name:(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one
CAS No.:700370-39-4
Molecular Formula:C₁₃H₁₂FIN₄O₃
Molecular Weight:418.166
Hs Code.:

Synonyms:(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

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Chemical Property of (R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

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Technology Process of (R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

There total 3 articles about (R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 487041-08-7
(5R)-3-(3-fluoro-4-iodo-phenyl)-5-hydroxymethyl-1,3-oxazolidin-2-one

: 700370-39-4
(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

2: sodium azide / dimethyl sulfoxide / 5 h / 90 °C

3: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 16 h / 50 °C

With sodium azide; copper(II) sulfate; sodium L-ascorbate; triethylamine; In dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2017.10.018

Reference yield:

: 372-19-0
meta-fluoroaniline

: 700370-39-4
(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.08 h / 0 °C

1.2: 3 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

5.1: sodium azide / dimethyl sulfoxide / 5 h / 90 °C

6.1: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 16 h / 50 °C

With N-iodo-succinimide; sodium azide; sodium hydrogencarbonate; copper(II) sulfate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2017.10.018

Reference yield:

: 149524-42-5
(5R)-3-(3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one

: 700370-39-4
(R)-3-(3-fluoro-4-iodophenyl)-5-((4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)methyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

3: sodium azide / dimethyl sulfoxide / 5 h / 90 °C

4: sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol; water / 16 h / 50 °C

With N-iodo-succinimide; sodium azide; copper(II) sulfate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2017.10.018