{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester
CAS No.:1415654-63-5
Molecular Formula:C₂₈H₃₆F₃NO₅S
Molecular Weight:555.659
Hs Code.:

{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Synonyms:{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

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Chemical Property of {5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of {5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

There total 3 articles about {5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415654-44-2
[5-(3-isopropyl-5-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

: 74-88-4
methyl iodide

: 1415654-63-5
{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1415654-18-0
[5-(3-isopropenyl-5-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

: 1415654-63-5
{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

2: potassium carbonate / dichloromethane / 16 h / 20 °C

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1415654-28-2
[5-(3-bromo-5-trifluoromethyl-benzenesulfonylamino)-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy]-acetic acid tert-butyl ester

: 1415654-63-5
{5-[(3-isopropyl-5-trifluoromethyl-benzenesulfonyl)-methyl-amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-1-yloxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 16 h / 100 °C / Inert atmosphere; Sealed tube

2: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

3: potassium carbonate / dichloromethane / 16 h / 20 °C

With hydrogen; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; 1: Suzuki Coupling;