(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

Base Information

Chemical Name:(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol
CAS No.:940959-58-0
Molecular Formula:C₂₄H₂₇NO₂
Molecular Weight:361.484
Hs Code.:

Synonyms:(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

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Technology Process of (1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

There total 1 articles about (1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 253675-63-7
(2S)-2-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-2-hydroxy-1,2-diphenylethanone

: 940959-58-0
(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

Guidance literature:: With lithium aluminium tetrahydride; tert-butyl alcohol; In diethyl ether; at 0 ℃; for 1h; Reagent/catalyst; diastereospecific reaction;
DOI:10.1134/S0022476619040176

Reference yield: 100.0%

: 940959-58-0
(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

: 74-88-4
methyl iodide

: (1S)-1-{2-[(1S,2R)-1,2-dihydroxy-1,2-diphenylethyl]phenyl}ethyl(trimethyl)ammonium iodide

Guidance literature:: In acetone; at 0 ℃;
DOI:10.1134/S1070428006070104

Reference yield:

: 940959-58-0
(1S,2R)-1-{2-[(1S)-1-(dimethylamino)ethyl]phenyl}-1,2-diphenylethane-1,2-diol

: 940959-62-6
(R)-[(1S,3R)-3-methyl-1-phenyl-1,3-dihydroisobenzofuran-1-yl]phenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / acetone / 0 °C

2: 78 percent / sodium acetate / dimethylformamide / Heating

With sodium acetate; In N,N-dimethyl-formamide; acetone;
DOI:10.1134/S1070428006070104