(-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine

Base Information

• Chemical Name: (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine
• CAS No.: 188785-98-0
• Molecular Formula: C₂₁H₂₁BrCl₂N₂O₂
• Molecular Weight: 484.22

Synonyms:(-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine

Chemical Property of (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine

Chemical Property:

Purity/Quality:

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Technology Process of (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine

There total 7 articles about (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromoacetyl bromide (598-21-0) + (+)-[3,5-dimethylbenzoyl]-3(R)-(3,4-dichlorophenyl)piperazine (188785-93-5) → (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine (188785-98-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;

DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

(+)-[3,5-dimethylbenzoyl]-3(R)-(3,4-dichlorophenyl)piperazine (188785-93-5) → (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine (188785-98-0)

Guidance literature:

Reference yield:

3,5-dimethylbenzoic acid (499-06-9) → (-)-bromoacetyl-2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)piperazine (188785-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HOBT; Et₃N; DEC / 0 °C

2: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

With diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(02)00645-5

upstream raw materials:

2-Bromoacetyl bromide

(+)-[3,5-dimethylbenzoyl]-3(R)-(3,4-dichlorophenyl)piperazine

3,5-dimethylbenzoic acid

methyl 2-(3,4-dichlorophenyl)acetate

Downstream raw materials:

(-)-1,1-dimethylethyl 4-[[2-[2(R)-(3,4-dichlorophenyl)-1-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethyl]amino]-1-piperidinecarboxylate

(exo)-1,1-dimethylethyl 5-[2-[2(R)-(3,4-dichlorophenyl)-4-(3,5-dimethylbenzoyl)-1-piperazinyl]-2-oxoethoxy]-1-(R),4(R)-2-azabicyclo[2.2.1]heptane-2-carboxylate

[2-(4-{2-[2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

[(S)-2-(4-{2-[(R)-2-(3,4-Dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-1-(4-hydroxy-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

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