[(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 207404-75-9
• Molecular Formula: C₄₀H₄₉Cl₂N₅O₅
• Molecular Weight: 750.766

Synonyms:

Chemical Property of [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

There total 9 articles about [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(3,4-dichlorophenyl)acetate (6725-44-6) → [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (207404-75-9)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NBS

2.1: LAH / diethyl ether

2.2: N-acetyl-L-leucine

3.1: HOBT; Et₃N; DEC / 0 °C

4.1: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

5.1: (i-Pr)2NEt / CH₂Cl₂

6.1: HCl / dioxane

7.1: HOBT; Et₃N; DEC

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

α-bromo-3,4-dichlorophenylacetic acid methyl ester (163339-71-7) → [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (207404-75-9)

Guidance literature:

Multi-step reaction with 7 steps

1.1: LAH / diethyl ether

1.2: N-acetyl-L-leucine

2.1: HOBT; Et₃N; DEC / 0 °C

3.1: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

4.1: (i-Pr)2NEt / CH₂Cl₂

5.1: HCl / dioxane

6.1: HOBT; Et₃N; DEC

With hydrogenchloride; lithium aluminium tetrahydride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(02)00645-5

Reference yield:

(2S)-2-(3,4-dichlorophenyl)piperazine (188788-22-9) → [(S)-1-Benzyl-2-(4-{2-[(R)-2-(3,4-dichloro-phenyl)-4-(3,5-dimethyl-benzoyl)-piperazin-1-yl]-2-oxo-ethylamino}-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (207404-75-9)

Guidance literature:

Multi-step reaction with 5 steps

1: HOBT; Et₃N; DEC / 0 °C

2: (i-Pr)2NEt / CH₂Cl₂ / -78 °C

3: (i-Pr)2NEt / CH₂Cl₂

4: HCl / dioxane

5: HOBT; Et₃N; DEC

With hydrogenchloride; diethylcarbamazine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/S0960-894X(02)00645-5

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

(-)-2(R)-(3,4-Dichlorophenyl)-4-[3,5-dimethylbenzoyl]-1-[(4-piperidinyl-amino) acetyl]piperazine

methyl 2-(3,4-dichlorophenyl)acetate

α-bromo-3,4-dichlorophenylacetic acid methyl ester

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