(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

Base Information

Chemical Name:(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine
CAS No.:1609497-10-0
Molecular Formula:C₂₂H₂₇NOS
Molecular Weight:353.528
Hs Code.:

Synonyms:(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

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Chemical Property of (E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

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Technology Process of (E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

There total 5 articles about (E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1609496-77-6
2-(4-bromo-3-((pent-2-yn-1-ylthio)methyl)phenoxy)-N,N-dimethylethanamine

: 98-80-6
phenylboronic acid

: 1609497-10-0
(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 2-methyltetrahydrofuran; water; at 130 ℃; for 3h; Microwave irradiation; Sealed tube;
DOI:10.1021/ol501165h

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 1609497-10-0
(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

Guidance literature:: Multi-step reaction with 5 steps

1: acetone / 20 °C

2: boron tribromide / dichloromethane / 12 h / 0 - 20 °C

3: potassium hydroxide / ethanol / 0.5 h / 20 °C

4: sodium hydroxide / toluene / 8 h / 120 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 2-methyltetrahydrofuran; water / 3 h / 130 °C / Microwave irradiation; Sealed tube

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium hydroxide; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; dichloromethane; water; acetone; toluene; 5: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol501165h

Reference yield:

: 1609496-74-3
S-(2-bromo-5-methoxybenzyl)ethanethioate

: 1609497-10-0
(E)-N,N-dimethyl-2-((4-(1-phenylpropylidene)isothiochroman-7-yl)oxy)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 12 h / 0 - 20 °C

2: potassium hydroxide / ethanol / 0.5 h / 20 °C

3: sodium hydroxide / toluene / 8 h / 120 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / 2-methyltetrahydrofuran; water / 3 h / 130 °C / Microwave irradiation; Sealed tube

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; potassium hydroxide; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; dichloromethane; water; toluene; 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol501165h