acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

Base Information

Chemical Name:acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester
CAS No.:661485-46-7
Molecular Formula:C₂₇H₃₈N₄O₁₀Si
Molecular Weight:606.705
Hs Code.:

acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

Synonyms:acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

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Chemical Property of acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

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Technology Process of acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

There total 5 articles about acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 661485-44-5
3'-[N-(benzyloxycarbonyl)aminomethyl]-2'-O-tert-butyldimethylsilyl-3'-deoxyuridine

: 661485-46-7
acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: DMSO; trifluoroacetic acid; pyridine / 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide / toluene / 1 h / 20 °C

1.2: sodium methoxide / methanol / 1.5 h / 20 °C

2.1: p-toluenesulfonic acid monohydrate / 1.5 h / 20 °C

With pyridine; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In toluene;
DOI:10.1021/jo060457c

Reference yield:

: 906795-53-7
3'-[N-(benzyloxycarbonyl)aminomethyl]-2'-O-tert-butyldimethylsilyl-3'-deoxy-5'-O-(4-methoxytrityl)uridine

: 661485-46-7
acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / dichloroacetic acid; triethylsilane / CH₂Cl₂ / 0.25 h / 20 °C

2.1: DMSO; trifluoroacetic acid; pyridine / 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide / toluene / 1 h / 20 °C

2.2: sodium methoxide / methanol / 1.5 h / 20 °C

3.1: p-toluenesulfonic acid monohydrate / 1.5 h / 20 °C

With pyridine; triethylsilane; dichloro-acetic acid; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; toluene;
DOI:10.1021/jo060457c

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 661485-46-7
acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 93 percent / NaOH / dioxane; H₂O / 0.33 h / 20 °C / pH 9

2.1: 77 percent / dichloroacetic acid; triethylsilane / CH₂Cl₂ / 0.25 h / 20 °C

3.1: DMSO; trifluoroacetic acid; pyridine / 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide / toluene / 1 h / 20 °C

3.2: sodium methoxide / methanol / 1.5 h / 20 °C

4.1: p-toluenesulfonic acid monohydrate / 1.5 h / 20 °C

With pyridine; triethylsilane; dichloro-acetic acid; sodium hydroxide; toluene-4-sulfonic acid; dimethyl sulfoxide; trifluoroacetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; water; toluene;
DOI:10.1021/jo060457c