Chemical Property of (4R,5S,6S)-3-[(5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Chemical Property:
- Vapor Pressure:2.27E-18mmHg at 25°C
- Refractive Index:1.639
- Boiling Point:627.4 °C at 760 mmHg
- Flash Point:333.2 °C
- PSA：163.17000
- Density:1.42 g/cm3
- LogP:-0.23420
- Storage Temp.:?20°C
- Solubility.:Soluble in aqueous solution at approximately 5mg/ml
- XLogP3:-2.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:5
- Exact Mass:383.15149208
- Heavy Atom Count:26
- Complexity:679
- Purity/Quality:
-
99% *data from raw suppliers
Meropenem Trihydrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O
- Isomeric SMILES:C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O
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Uses
Meropenem trihydrate is a carbapenem antibiotic with wide spectrum of antibacterial. It is an ultra-broad spectrum beta-lactam antibiotic and has antibacterial activity against Gram-negative and Gram-positive bacteria as well as anaerobic microorganisms such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter species, Serratia marcescens, Streptococcus pyogenes, Streptococcus agalactiae and Citrobacter sp. Meropenem trihydrate is indicated for the treatment of serious bacterial infection including complicated skin infections, complicated intra-abdominal infections, urinary tract infections, severe pneumonia, broncho-pulmonary infections and bacterial meningitis.
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Clinical Use
Meropenem is a second-generation carbapenem that, todate, has undergone the most extensive clinical evaluation.It has recently been approved as Merrem for the treatmentof infections caused by multiply-resistant bacteria and forempirical therapy for serious infections, such as bacterialmeningitis, septicemia, pneumonia, and peritonitis.Meropenem exhibits greater potency against Gram-negativeand anaerobic bacteria than does imipenem, but it is slightlyless active against most Gram-positive species. It is not effectiveagainst MRSA. Meropenem is not hydrolyzed byDHP-I and is resistant to most β-lactamases, including a fewcarbapenemases that hydrolyze carbapenem.
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Indications
Intra-abdominal infectionsBacterial meningitis (pediatric patients >3 months)Complicated skin and skin structure infections
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Drug interactions
Potentially hazardous interactions with other drugs
Antiepileptics: concentration of valproate reduced -
avoid.
Probenecid: avoid concomitant use
