96034-64-9Relevant articles and documents
A penem medicine intermediate and a preparing method thereof
-
, (2016/10/17)
A penem medicine intermediate and a preparing method thereof are provided. The penem medicine intermediate is (2S,4R)-4-(3-fluorophenylthio)pyrrolidine-2-carboxylic acid (shown as the formula IV). The intermediate is prepared by a one-step reaction by subjecting trans-4-hydroxy-L-proline and 3,3'-difluoro diphenyl disulfide which are adopted as initial raw materials to disulfide bond breaking under actions of a reductant. The intermediate is simple in preparing method, easily available in raw materials, low in environment pollution and suitable for large-scale industrial production, and can be used for preparing penem medicine mercaptan branch chains or penem medicines.
AN IMPROVED PROCESS FOR THE PREPARATION OF PYRROLIDINE THIOL DERIVATIVES USEFUL IN THE SYNTHESIS OF CARBAPENEM COMPOUNDS
-
Page/Page column 10, (2012/09/11)
The present invention relates to an improved process for the preparation of the compound of formula (III) which is used in the synthesis of carbapenem antibiotics. wherein R3 is hydrogen or an amine protecting group.
AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC
-
Page/Page column 22, (2010/09/17)
The present invention relates to an improved process for the preparation of the carbapenem antibiotic of formula (I) or its salts, hydrates and esters. The present invention further provides novel crystalline form of compound of general formula (III), wherein R3 is p-nitrobenzyloxy carbonyl.