N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Base Information

• Chemical Name: N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
• CAS No.: 1342899-83-5
• Molecular Formula: C₂₄H₂₀F₃N₃O₂S
• Molecular Weight: 471.503
• Mol file: 1342899-83-5.mol

Synonyms:N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Chemical Property of N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

There total 3 articles about N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-dibenzyl-p-iodobenzenesulfonamide (428486-70-8) + 3-(trifluoromethyl)pyrazole (20154-03-4) → N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (1342899-83-5)

Guidance literature:

With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 24h;

DOI:10.1016/j.tet.2020.131680

Reference yield:

p-Iodobenzenesulfonyl chloride (98-61-3) → N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (1342899-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: copper(l) iodide; potassium phosphate; N,N-dimethyl-cyclohexanamine / 1,4-dioxane / 50 h / 115 °C

With potassium phosphate; copper(l) iodide; N,N-dimethyl-cyclohexanamine; triethylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.tetlet.2011.08.174

Reference yield:

dibenzylamine (103-49-1) → N,N-dibenzyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (1342899-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 24 h / 130 °C

With copper(l) iodide; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2020.131680

upstream raw materials:

N,N-dibenzyl-p-iodobenzenesulfonamide

3-(trifluoromethyl)pyrazole

p-Iodobenzenesulfonyl chloride

dibenzylamine

Downstream raw materials:

4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide

N,N-dibenzyl-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide