N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Base Information

Chemical Name:N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide
CAS No.:519058-41-4
Molecular Formula:C₂₃H₂₄F₃N₃O₂S
Molecular Weight:463.524
Hs Code.:

<i>N</i>-{4-[4-(3-trifluoromethyl-phenyl)-1<i>H</i>-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Synonyms:N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

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Chemical Property of N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

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Technology Process of N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

There total 5 articles about N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27687-12-3
(1r,4r)-4-({[(benzyloxy)carbonyl]amino}methyl)cyclohexane-1-carboxylic acid

: 519058-41-4
N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-yloxytris(dimethylamino)phosphonium*PF₆^1-; triethylamine / dimethylformamide / 80 °C

2: AcOH; NH₄OAc / 16 h / Heating

3: H₂ / Pd/C / ethanol / 2844.31 Torr

4: triethylamine / CH₂Cl₂ / 2 h / 20 °C

With ammonium acetate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030490g

Reference yield:

: 61062-56-4
2-amino-1-(3-(trifluoromethyl)phenyl)ethan-1-one hydrochloride

: 519058-41-4
N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-yloxytris(dimethylamino)phosphonium*PF₆^1-; triethylamine / dimethylformamide / 80 °C

2: AcOH; NH₄OAc / 16 h / Heating

3: H₂ / Pd/C / ethanol / 2844.31 Torr

4: triethylamine / CH₂Cl₂ / 2 h / 20 °C

With ammonium acetate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030490g

Reference yield:

: 519058-32-3
trans-N-{2-oxo-2-[3-(trifluoromethyl)phenyl]ethyl}(4-{[(phenylmethoxy)carbonylamino]methyl}cyclohexyl)carboxamide

: 519058-41-4
N-{4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexylmethyl}-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH; NH₄OAc / 16 h / Heating

2: H₂ / Pd/C / ethanol / 2844.31 Torr

3: triethylamine / CH₂Cl₂ / 2 h / 20 °C

With ammonium acetate; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm030490g