Diatrizoate sodium

Base Information

• Chemical Name: Diatrizoate sodium
• CAS No.: 737-31-5
• Molecular Formula: C11H9 I3 N2 O4 . Na
• Molecular Weight: 635.899
• Hs Code.: 29242100
• Mol file: 737-31-5.mol

Synonyms:Benzoicacid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt (9CI); Benzoic acid,3,5-diacetamido-2,4,6-triiodo-, monosodium salt (8CI); Benzoic acid,3,5-diacetamido-2,4,6-triiodo-, sodium salt (6CI);3,5-Diacetamido-2,4,6-triiodobenzoic acid sodium salt; Diatrizoate sodium;Hypaque; Hypaque 50; Hypaque sodium; Radioselectan; Sodium3,5-diacetamido-2,4,6-triiodobenzoate; Sodium amidotrizoate; Sodiumdiatrizoate; Triombrin; Triombrine; Urografic acid sodium salt; Urografin S;Urographing 370; Urovist 300

Chemical Property of Diatrizoate sodium

Chemical Property:

• Melting Point: 261-262° (dec)
• Boiling Point: 614.1 °C at 760 mmHg
• Flash Point: 325.2 °C
• PSA: 98.33000
• LogP: 1.92670
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: H2O: 0.35 g/mL, slightly turbid, colorless

Purity/Quality:

≥98.5% ^*data from raw suppliers

Sodium Diatrizoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Diatrizoate sodium is a contrast agent used during the X-rays test. It can be used as a diagnostic aid agent during angiography, urography and radiography. It can be applied during visualizing veins, the urinary system, gastrointestinal tract, spleen and joints as well as during the computer tomography (CT scan). It is used in cases where barium is not suitable for application such as patient being allergic to barium. The mechanism of action of Diatrizoate sodium is that it can block the X-rays so that the body structure containing iodine to be delineated in contrast to those structures that free of iodine, further allowing the visualization of those related areas.
• Uses: Diagnostic aid (radiopaque medium).
• Therapeutic Function: Diagnostic aid (radiopaque medium)

Technology Process of Diatrizoate sodium

There total 2 articles about Diatrizoate sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ sodium diatrizoate (737-31-5)

Guidance literature:

Reference yield:

diatrizoic acid (117-96-4) → sodium diatrizoate (737-31-5)

Guidance literature:

With sodium carbonate; In water;

DOI:10.1002/chem.201404693

Reference yield: 76.0%

sodium diatrizoate (737-31-5) + chloroacetic acid ethyl ester (105-39-5) → Ethyl (3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)acetate (5714-09-0)

Guidance literature:

In N,N-dimethyl-formamide;

upstream raw materials:

diatrizoic acid

Downstream raw materials:

Propanedioic acid, [[3,5-bis(acetylamino)-2,4,6-triiodobenzoyl]oxy]methyl-bis(1-methylethyl)ester

Ethyl (3,5-bis(acetylamino)-2,4,6-triiodobenzoyloxy)acetate

3,5-diamino-2,4,6-triiodobenzoic acid

Refernces

• 1、 -. "X-ray contrast media for prolonged opacification". . . Retrieved 2008/06/13.