(4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone

Base Information

• Chemical Name: (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone
• CAS No.: 219506-00-0
• Molecular Formula: C₁₇H₁₅ClO₃S₂
• Molecular Weight: 366.889
• Mol file: 219506-00-0.mol

Synonyms:(4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone

Chemical Property of (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone

There total 4 articles about (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[b]thiophen-2-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-chlorobenzoyl)benzo[b]thiophene 1-oxide (163083-14-5) + 2-hydroxyethanethiol (60-24-2) → (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ4-benzo[b]thiophen-2-yl]-methanone (219506-00-0)

Guidance literature:

With sodium methylate; In methanol; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00929-6

Reference yield:

benzo[b]thiophen-2-yl-(4-chloro-phenyl)-methanol (6314-41-6) → (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ4-benzo[b]thiophen-2-yl]-methanone (219506-00-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / MnO₂ / diethyl ether / 7 h / Ambient temperature

2: 85 percent / aq. H₂O₂ / trifluoroacetic acid / 1 h / 0 °C

3: 95 percent / MeONa / methanol / 2 h / Ambient temperature

With manganese(IV) oxide; dihydrogen peroxide; sodium methylate; In methanol; diethyl ether; trifluoroacetic acid;

DOI:10.1016/S0040-4020(98)00929-6

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (4-Chloro-phenyl)-[3-(2-hydroxy-ethylsulfanyl)-1-oxo-2,3-dihydro-1H-1λ4-benzo[b]thiophen-2-yl]-methanone (219506-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) ether, hexane, reflux, 1.5 h, 2.) ether, hexane, room temp., 1.5 h

2: 85 percent / MnO₂ / diethyl ether / 7 h / Ambient temperature

3: 85 percent / aq. H₂O₂ / trifluoroacetic acid / 1 h / 0 °C

4: 95 percent / MeONa / methanol / 2 h / Ambient temperature

With manganese(IV) oxide; n-butyllithium; dihydrogen peroxide; sodium methylate; In methanol; diethyl ether; trifluoroacetic acid;

DOI:10.1016/S0040-4020(98)00929-6

upstream raw materials:

2-(4-chlorobenzoyl)benzo[b]thiophene 1-oxide

2-hydroxyethanethiol

benzo[b]thiophen-2-yl-(4-chloro-phenyl)-methanol

4-chlorobenzaldehyde