(E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole

Base Information

• Chemical Name: (E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole
• CAS No.: 1380503-00-3
• Molecular Formula: C₂₆H₁₉N₃
• Molecular Weight: 373.457
• Mol file: 1380503-00-3.mol

Synonyms:(E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole

Chemical Property of (E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole

There total 1 articles about (E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(2-pyrimidyl)indole (221044-05-9) + diphenyl acetylene (501-65-5) → (E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole (1380503-00-3)

Guidance literature:

With 2-(2-(diphenylphosphino)ethyl)pyridine; neopentylmagnesium bromide; cobalt(II) bromide; In tetrahydrofuran; at 20 ℃; for 12h; stereoselective reaction;

DOI:10.1002/anie.201200019

Reference yield: 93.0%

(E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole (1380503-00-3) → 2-(1,2-diphenylvinyl)-1H-indole

Guidance literature:

With sodium ethanolate; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1002/anie.201200019

Reference yield:

(E)-2-(1, 2-diphenylvinyl)-1-(pyrimidin-2-yl)-1H-indole (1380503-00-3) → C29H27NO2 + C29H27NO2

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / dimethyl sulfoxide / 100 °C

2: tert-Butyl peroxybenzoate; palladium diacetate / 1,4-dioxane; dimethyl sulfoxide / 18 h / 70 °C

With tert-Butyl peroxybenzoate; sodium ethanolate; palladium diacetate; In 1,4-dioxane; dimethyl sulfoxide; 2: Heck olefination;

DOI:10.1002/anie.201200019

upstream raw materials:

N-(2-pyrimidyl)indole

diphenyl acetylene