cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Base Information

Chemical Name:cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride
CAS No.:134456-59-0
Molecular Formula:C₁₆H₂₃NO₃*ClH
Molecular Weight:313.824
Hs Code.:

Synonyms:cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

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Chemical Property of cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

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Technology Process of cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

There total 7 articles about cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 134456-09-0
cis-1-(aminomethyl)-3-cyclohexyl-5,6-(cyclohexylidenedioxy)-3,4-dihydro-1H-2-benzopyran

: 134456-59-0
cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; for 3h; Heating;
DOI:10.1021/jm00112a034

Reference yield:

: 3483-39-4
Cyclohexyloxirane

: 134456-59-0
cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) hexane, THF, RT, 4 h, 2.) hexane, THF, from 0 deg C to RT, 2 h

2: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

3: 75 percent / LiN₃ / dimethylformamide / 3 h / 70 °C

4: 98 percent / lithium aluminum hydride (LAH) / ethanol / 1 h / 0 °C

5: 87 percent / 5 M HCl / ethanol / 3 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; lithium azide; boron trifluoride diethyl etherate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a034

Reference yield:

: 134456-07-8
2-cyclohexyl-1-spiro<1,3-benzodioxole-2,1'-cyclohexane>-2-ethanol

: 134456-59-0
cis-1-(aminomethyl)-3-cyclohexyl-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / BF₃OEt₂ / diethyl ether / 24 h / Ambient temperature

2: 75 percent / LiN₃ / dimethylformamide / 3 h / 70 °C

3: 98 percent / lithium aluminum hydride (LAH) / ethanol / 1 h / 0 °C

4: 87 percent / 5 M HCl / ethanol / 3 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; lithium azide; boron trifluoride diethyl etherate; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a034